Medication-assisted treatment is a highly effective treatment method for substance use disorder (SUD) combining regularly ingested medications to decrease withdrawal with tailored behavioral and cognitive assistance. Public stigma and personal attitudes can impact the proliferation and efficacy of MAT services. Therefore, understanding the content and prevalence of relevant attitudes in rural communities is essential for efforts at improving the rural treatment landscape. The aim of this study was to (1) qualitatively examine the specific personal beliefs and attitudes (“belief factors”) among rural residents that contribute to their support or opposition to both MAT and government funding for MAT and (2) qualitatively examine the factors of rural social life which could influence those beliefs and attitudes. I identified eight core factors (generally categorizable as either empathy-related, political, or scientific beliefs) as influential for an individual’s level of support for MAT. I also identified three core social factors of rural life which could influence an individual’s level of support for MAT. These results contain critical implications for future literature and MAT-related messaging campaigns predicated upon individual belief systems.