Research Week 2: Science as a Piecewise Function
One of the biggest lessons I've learned this week is that research rarely follows a perfectly linear path. Experiments don't always work on the first try, timelines evolve, and sometimes the most valuable progress is made when you step back and rethink your approach.
That lesson came early this week during one of my Western blots. While transferring the proteins from the acrylamide gel to the membrane, I accidentally tore the gel and all my samples. Thankfully, with guidance from my supervisor (and a second attempt!), I was able to successfully repeat the transfer and produce clear protein bands. It was a reassuring reminder that mistakes are an inevitable part of research, and learning how to recover from them is just as important as getting things right the first time.
This week was also filled with opportunities to learn beyond the bench. I attended the final presentations of several master's students, where I was inspired by the breadth of research taking place across the institute. It gave me valuable insight into postgraduate research and a greater appreciation for how scientific discoveries are communicated beyond the laboratory.
The highlight of my second week was visiting the Cheney Biomedical Accelerator! During my visit, I had the opportunity to speak with Sally Boxall, the Research Facility Manager for Bioimaging and Flow Cytometry, and learn more about the incredible imaging technologies available within the facility. Seeing these instruments in person helped me better understand how advanced microscopy could complement my project.
As discussions with my supervisor became increasingly ambitious, it became clear that there were more ideas than could realistically be explored within six weeks. This is where the project management principles I learned during the Weetwood residential proved extremely valuable. By applying the Eisenhower matrix to prioritize our ideas, I was able to define a clear SMART goal for the summer, establishing a realistic roadmap with achievable milestones while keeping sight of the project's long-term vision.
This summer, our aim is to focus on advanced microscopy to better understand the intercellular mechanisms associated with Type 2 Diabetes. Our work will hopefully provide better context on the specific mechanisms and pathways that drive cardiometabolic disease, while presenting opportunities for future studies that look to translate this research into real clinical impact.
Although we won't have time to investigate every avenue this summer, that doesn't mean those ideas have been lost. Instead, we've developed a roadmap for future work that I could explore during a placement year, my third-year dissertation, or even in my postgraduate research.
I'm looking forward to seeing where Week 3 takes me, and hopefully keeping all my gels intact this time!
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