Glycan't Meet Deadlines: A Fashionably Late Project Outline
Developing a Novel Mass Measurement Technique for GAG's
School of Physics and Astronomy/Faculty of Biological Sciences , University of Leeds
James S McLean - , University of Leeds
Exploring Mass Photometry and Particle Tracking for Glycan Analysis
Supervised by: Prof. Richter, School of Physics and Astronomy, University of Leeds
Project Background: As a Physics undergraduate , I'm embarking on an exciting journey into the world of bio-nano-physics. This project combines cutting-edge mass photometry techniques with advanced particle tracking algorithms to study the behaviour of hyaluronan molecules diffusing on a solid-supported lipid bilayers in 2D .
Research Objectives:
- Develop proficiency in mass photometry techniques and professional lab methodologies.
- Implement and refine a mass-sensitive particle tracking algorithm.
- Create a novel measurement technique for determining the mass of hyaluronan molecules as they diffuse through a solid-supported lipid bilayer.
- Collaborate with a diverse team of professors, PhD students, and postgraduate researchers within the Richter research group.
Expected Outcomes: This project aims to contribute to our understanding of glycan behavior in biomimetic environments, potentially opening new avenues for research in fields such as drug delivery and cell membrane studies.
Skills Development: Throughout this project, I will be learning professional lab techniques, data analysis methods, and collaborative research practices from scratch. This hands-on experience will provide invaluable insights into the world of academic research and biophysics.
Stay tuned for updates on this exciting venture into the microscopic world of glycans and lipid bilayers!
Hello!
My name is James McLean, and I am currently pursuing an integrated master’s program in Physics at the University of Leeds.
My research project , in the realm of Bio-nano-Physics , focuses on an imaging technique known as mass photometry, which aims to observe the landing sites of polysaccharides without the necessity for external markers.
My passion for applied physics is diverse, stretching from the medical field to aerospace and aeronautical engineering. I am actively involved with the Leeds University Rocketry Association (LURA), where we aim to break the UKRA amateur University record . Additionally, I have a keen interest in pure physics, drawing inspiration from groundbreaking research at institutions like CERN.
I am eager to connect with other ambitious and determined individuals who are committed to leveraging scientific innovation to benefit society and humanity. Let’s collaborate to make a significant impact!
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