Poster Biomedical Sciences Neuroscience
Medicine & Health, STEM, Research, University of Leeds, Leadership & Research Laidlaw Scholars

Research Poster: Investigating the Role of Alpha-Synuclein Charge in Synaptic Vesicle Fusion and Neurotransmitter Release Using Mass Spectrometry

α-Synuclein is a neuronal protein essential for regulating neurotransmitter release, but its abnormal aggregation is implicated in synucleinopathies. This study examines how its charge state affects interactions with membrane lipids, using mass spectrometry to reveal molecular insights.
Go to the profile of Dawit Negasi
Dawit Negasi
Laidlaw Scholar, University of Leeds
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Research Report 2025: Investigating the Role of Alpha-Synuclein Charge in Synaptic Vesicle Fusion and Neurotransmitter Release Using Mass Spectrometry

Studying how the neuronal protein α-synuclein interacts with signalling lipids to regulate vesicle fusion and neurotransmitter release. Using advanced mass spectrometry, this study reveals molecular insights into mechanisms underlying Parkinson’s disease and related synucleinopathies.
Go to the profile of Dawit Negasi
Dawit Negasi (He/Him)
Laidlaw Scholar, University of Leeds

Hello! I am a 2025 Laidlaw Scholar from the University of Leeds, currently studying Biomedical Science. My research explores the role of alpha-synuclein charge in synaptic vesicle fusion and neurotransmitter release using mass spectrometry approch.

As a naturally curious and interdisciplinary thinker, I’m passionate about learning from diverse perspectives and connecting with others who are driven by purpose, innovation, and leadership—whatever their field may be.

I’d love to connect, collaborate, and grow together as part of this dynamic global network.

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