The stoichiometry of the CD4/Lck complex in T cells

Supervisor: Simon Davis Organisation: Weatherall Institute of Molecular Medicine, University of Oxford Year of Scholarship: 2018

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Alexander Morch

PhD student, University of Oxford

I'm a student of the Infection, Immunology and Translational Medicine PhD program at the University of Oxford, funded by the Wellcome Trust. My research is focused on the activation of the human immune system, specifically on how T cell coreceptors CD4 and CD8 contribute to lymphocyte activation by integrating signaling through the TCR. Although CD4 and CD8 are responsible for the extraordinary sensitivity of T cells to antigen, the molecular mechanisms by which they function are unclear. I am investigating the relative organization and dynamics of coreceptors as they accumulate at the immunological synapse through super-resolution imaging, spectroscopy, and biochemical analysis. This project is a collaborative effort with Prof. Simon Davis (Weatherall Institute of Molecular Medicine) with whom I undertook both my Masters’ project and a Laidlaw Scholarship.